On-Demand Computational Histopathology

Computational Pathology Image analysis Services CRO
San Diego, CA · Digital Pathology CRO

Image Analysis Services
On-Demand.

Advanced image analysis services for histology and histopathology — delivering quantitative, pathologist-validated insights for IHC, multiplex immunofluorescence, and multiplex immunohistochemistry assays — without building an in-house imaging division. You send tissue, slides, or whole-slide images; we return decision-ready data.

Glint Lab delivers 100% of the capability at a fraction of the time and loaded cost of standing up the equivalent in-house.

Deployment Time

weeks to first results
Hiring experts & training24w
Infrastructure build / IT upkeep12w
Internal alignment meetings8w
Glint Lab — avg. project time4w
1/12th
the time
to results

Total Loaded Cost

USD, per program
Salary & benefits$150k+
Software, GPU hardware & servers$100k+
IT / facility overhead$80k+
Glint Lab — flat project fee$15k
1/22nd
the cost
Image Analysis Services

Analytical workflows for translational targets

Our image analysis services provide comprehensive workflows for histology and histopathology across IHC, multiplex immunofluorescence (mIF), and multiplex immunohistochemistry assays — from single markers to whole-tissue spatial biology.

Quantitative

Histopathology image analysis for cell counts, area metrics, staining intensity, IHC and multiplex phenotyping, tumor purity, immune infiltration.

Spatial

Multiplex immunofluorescence (mIF) and multiplex immunohistochemistry (mIHC) spatial analysis — clustering, proximity, infiltration, density profiling.

Predictive AI

Histology-based prediction models — mutation prediction, automated IHC scoring, disease and treatment outcome modeling.

Our Capabilities

A solution built around your study.

Full-Spectrum Service

Integrated histology, pathology, and computational analysis under one roof.

RUO & Regulatory-Ready

Flexible to your study design and quality needs, from exploratory to audit-ready.

Pathologist-Validated

Reproducible, audit-ready, and consistent across platforms and cohorts.

Flagship Analytical Solutions

High-value actionable insights for translational programs

H-Score Automation
IHC / DAB Staining

H-Score Automation

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IHC / DAB Staining

H-Score Automation

  • H-Score (0–300 scale)
  • % positive cells
  • Staining intensity

Know exactly how much your target is expressed — eliminating inter-pathologist variability.

Spatial Immune Profiling
IHC / mIF / Spatial Biology

Spatial Immune Profiling

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IHC / mIF / Spatial Biology

Spatial Immune Profiling

  • Cell-to-cell proximity metrics
  • TME compartment densities
  • Immune infiltration classification

Not just which cells are present, but where — revealing resistance & immune exclusion.

Multiplex IF Quantification
mIF / OPAL / Tyramide

Multiplex IF Quantification

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mIF / OPAL / Tyramide

Multiplex IF Quantification

  • Multi-marker co-expression
  • Neighborhood analysis & clustering
  • Per-channel intensity metrics

Characterize every immune population in one section — built for I-O, CAR-T & checkpoint.

H&E Morphology Analysis
Hematoxylin & Eosin

H&E Morphology Analysis

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Hematoxylin & Eosin

H&E Morphology Analysis

  • % tumor area, stroma, necrosis
  • Dermal / epidermal thickness
  • Immune infiltration scoring

Remove subjectivity from efficacy & safety reads — standardized across every cohort.

Biologics & ADC
RNA & Protein

Biologics & ADC

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RNA & Protein

Biologics & ADC

  • Advanced RNA & protein quantification
  • Target assessment & validation
  • RNAscope puncta enumeration

De-risk biologic and antibody-drug-conjugate programs with quantitative target validation.

↻ Click any card to see the analytical details

What you get back

Digital pathology, turned into quantitative biology

Comprehensive quantitative outputs for open-ended exploration, backed by pathology experts.

Quantification

Biomarker Expression

Positive cell counts, area, %, density & intensity — IHC, IF & special stains.

Staining Artifact QC

Uneven staining, blur, folds, background — objective pass/fail.

Subcellular Localization

Compartment mapping: membrane, cytoplasm, nucleus.

Co-expression / Co-localization

Multi-marker phenotyping in heterogeneous tissue & TME.

RNA Puncta (ISH)

Binned dot counts per cell.

Scoring & Morphology

H-Scoring

Intensity-weighted scoring for standardized cohort comparison.

Skin & Epidermal Measurement

Epidermal thickness, layer identification, cross-sectional analysis.

Muscle Fiber Morphology

Fiber type, area, diameter, centralized nuclei — regeneration & degeneration.

Collagen & Connective Tissue

Fiber length, branching, orientation & anisotropy, fibrosis quantification.

Specialized Structures

NMJ morphology, microneedle penetration-site identification.

Tissue Context & QA

Tissue Region Segmentation

Tumor, stroma, dermal / epidermal layers, TLS, and more.

Lipid & Inflammation

Steatosis (micro / macro droplets) & immune-cell infiltration density.

Metastatic Lesion Enumeration

Detect, count & measure metastatic burden.

Histopathology Scoring Systems

NASH, OARSI, Ashcroft, Ishak, and more — automated & objective.

Comparative Staining Analysis

Cross-reagent & cross-platform assay validation.

Algorithm Library

A deep repository of image-analysis algorithms

Spanning oncology, neuroscience, fibrosis, dermatology, muscle, and metabolic disorders — off-the-shelf or custom-trained.

5LO, ArteriosclerosisHER2-FISH, Breast CancerOrcein Staining, SkinAdipophilin, Fatty LiverHER2-SISH, Breast Cancerp16+Ki-67, Cervical Ca, ICCALK, Cell Lines, CancerHER2, Cell Lines, CancerPAS+PCK, Salivary GlandAnnexin 10, Bladder CancerHER2/HER3, Breast CancerPCK, Tumor Budding, CRCaSMA+Col IV, Breast CancerIHC, Glomeruli Detect., AIPD-L1 RISH, Lung Ca, TMEBovine/Pig, OsteoarthritisiNOS, Melanoma, TMEPD-L1, Cell Lines, CancerBRAF, Cell Lines, CancerInvasive Tumor Detect. (PDS)PD-L1, Germinal CenterCD15, Hodgkin’s LymphomaInvasive Tumor Detect. (VDS)PD-L1, Melanoma, TMECD15, Kidney CancerIron Hematoxylin, AdiposePD-L1+SOX10, MelanomaCD3, Lung TransplantationKi-67+CK5 VDS, Neck CancerPHH3+CK5 VDS, Neck CancerCD3, Lymphocytic ColitisKi-67, Epidermal HyperplasiaPHH3, Breast CancerCD3+CD20+CK, Sjögren’sKi-67, Neuroendocrine Neo.PHH3+PCK, Breast CancerCD31, Tumor Neovasc.Ki-67, Pancreatic CancerPicrosirius Red, SADSCD31+CD34, Kidney CancerKi-67+MART1, MelanomaPR, Cell Lines, CancerCD56, Endometrial TissueKi-67+p16, Cervical CancerProstate Cancer Detect., AICD57, Ovarian Cancer, TMEKi-67+PanCK, Breast CancerPSR, Liver Fibrosis AICD68 & CD163, Breast, TMEm-PGES1, Melanoma, TMERat, Cell body & NeuriteCD74, Melanoma, TMEmCherry+GFP, Axon DensityRat, Corneal Neovasc.
+ 100 more algorithms available

Anchored in full-service histopathology: IHC (100+ antibodies) · multiplex IF · RNAscope · special stains · whole-slide imaging

Transparent Reporting

Actionable insights you can publish and defend

Our image analysis services deliver comprehensive documentation, graphs, and visualizations from histopathology and multiplex immunofluorescence assays — built for reproducibility and informed decisions.

  • Publication-ready graphs: high-resolution plots of distribution, density, and positive-percentage trends.
  • Pathology integration: results aligned and reviewed alongside pathologist analysis.
  • Complete metadata audit trails: full documentation of pipeline logic for end-to-end traceability.
  • Tissue microenvironment matrices: spatial layouts mapping absolute metrics and proximity relationships.
Sample analytical outputs: bar chart of positive-cell percentage by sample, box plot by group, RNA puncta detection overlays, IHC field with density heatmap, and per-sample heatmap
Animated preview of a Glint Lab study report

Study charts, histograms & spatial heatmaps in every report

How we work with you

From samples to a final report in four steps

1

Consult

We start with your tissue samples, glass WSIs, and research goals.

2

Assay / Panel

We scope the assay panel and analysis workflow together with you.

3

Analyze

We develop and deploy novel algorithms or fine-tune existing ones.

4

Deliver

Quantitative data tables, visualizations, and a final report.

FAQ

Image analysis services: Common technical & engagement questions

We work interactively alongside your key stakeholders to iterate and fine-tune models directly against your slide cohorts.
Step 1 — Pilot evaluation

Initial calibration of artifact controls, signal-to-noise distributions, and cellular alignment targets.

Step 2 — Validation deployment

Cross-cohort model checking and rigorous edge testing against hidden or variable sample anomalies.

Glass slides or whole-slide images: IHC (standard and novel antibodies), multiplex IF (mIF), RNAscope ISH, and special stains (PSR, PAS, MTC, etc.), as well as other biological and biomedical images such as confocal and 3D tissue images.
Yes. The architecture uses secure cloud infrastructure with high-throughput, scalable compute, enabling real-time data inspection for cross-functional global teams without local IT overhead.
We support over 30 whole-slide and static image formats:
Proprietary Vendor Formats

Zeiss (`.czi`, `.lsm`), Leica (`.scn`), Olympus (`.oib`, `.vsi`), Nikon (`.nd2`), Aperio (`.svs`), Hamamatsu (`.ndpi`), Ventana (`.bif`), 3DHistech (`.mrxs`), Philips (`.isyntax`), Akoya / PerkinElmer (`.qptiff`)

General Formats

OME-TIFF (`.ome.tif`, `.ome.tf8`), TIFF/TIF, JPEG/JPG, and BMP

Upon completion of the analysis, a comprehensive report is generated including QC, quantitative data, or statistical analysis as initially laid out in the scope of work.
Yes, if included in the scope of work, we will deliver layered data including annotations and/or analysis masks in .mld, .geojson, .ome.xml, .tsv, or .tif / .tiff formats.
Yes, as a part of our fractional Image Analysis Services, we offer AWS storage and cloud-based digital pathology access. Long-term storage of digital pathology images is available upon request.
No, cloud computation is calculated in the cost of the regular project. For clinical deployment or custom models, a price per slide can be discussed for long-term usage.

Partner with Glint Lab

Get AI-driven image analysis services for publication-ready, quantifiable insights — from study design through final report. No imaging division required.